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Scandinavian Journal of Gastroenterology Volume 56, 2021 - Issue 7
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Original Article

Presence of interferon-λ 4, male gender, absent/mild steatosis and low viral load augment antibody levels to hepatitis C virus

Jesper Waldenströma Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;b Department of Infectious Diseases, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, SwedenORCID Iconhttps://orcid.org/0000-0003-2234-0076View further author information
ORCID Icon,
Kristoffer Hellstranda Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;c Department of Clinical Microbiology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, SwedenORCID Iconhttps://orcid.org/0000-0002-6617-5976View further author information
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Johan Westina Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;b Department of Infectious Diseases, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, SwedenView further author information
,
Staffan Nilssond Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden;e Department of Pathology and Genetics, Institute of Biomedicine, University of Gothenburg, Gothenburg, SwedenView further author information
,
Peer Christensenf Department of Infectious Diseases, Odense University Hospital, Odense, Denmark;g Institute of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, DenmarkView further author information
,
Martti Färkkiläh Department of Gastroenterology, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandORCID Iconhttps://orcid.org/0000-0002-0250-8559View further author information
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Kristine Mørchi Department of Clinical Science, University of Bergen, Bergen, NorwayView further author information
,
Nina Langelandi Department of Clinical Science, University of Bergen, Bergen, NorwayView further author information
,
Gunnar Norkransa Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;b Department of Infectious Diseases, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, SwedenView further author information
&
Martin Lagginga Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;c Department of Clinical Microbiology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, SwedenCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7995-3626View further author information
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Pages 849-854 | Received 01 Apr 2021, Accepted 20 Apr 2021, Published online: 02 Jun 2021

Figures & data

Table 1. Baseline characteristics of the 279 patients included in the study.

Figure 1. Signal-to-cutoff (S/CO) antibody ratio in relation to the absence of IFN-λ4 (IFNL4rs12979860 CC) or presence of IFN-λ4 (IFNL4rs12979860 CT/TT) (A), gender (B), and gender and IFN-λ4 (C). Median and interquartile range. Statistics using Mann–Whitney U test.

Figure 1. Signal-to-cutoff (S/CO) antibody ratio in relation to the absence of IFN-λ4 (IFNL4rs12979860 CC) or presence of IFN-λ4 (IFNL4rs12979860 CT/TT) (A), gender (B), and gender and IFN-λ4 (C). Median and interquartile range. Statistics using Mann–Whitney U test.

Figure 2. Signal-to-cutoff (S/CO) antibody ratio in anti-HCV antibody assay in relation to absent/mild or moderate/severe interface hepatitis (Ishak grade 0–2 versus 3–4) (A), and absent/mild or moderate/severe steatosis (grade 0–1 versus 2–3) (B). Median and interquartile range. Statistics using Mann-Whitney U-test.

Figure 2. Signal-to-cutoff (S/CO) antibody ratio in anti-HCV antibody assay in relation to absent/mild or moderate/severe interface hepatitis (Ishak grade 0–2 versus 3–4) (A), and absent/mild or moderate/severe steatosis (grade 0–1 versus 2–3) (B). Median and interquartile range. Statistics using Mann-Whitney U-test.

Table 2. Associations of baseline characteristics with anti-HCV S/CO ratio.

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