Changes in colonic enteroendocrine cells of patients with irritable bowel syndrome following fecal microbiota transplantation

Figures & data

Figure 1. IBS-SSS scores for (A) responders and (B) nonresponders IBS patients after receiving fecal microbiota transplantation.

Table 1. The densities of the enteroendocrine cells in the sigmoid colon of the total group of IBS patients before and after transplantation.

	Endocrine cells (cells/mm^2)
Hormone	IBS (total) n = 20		p Value
	Before	After
Chromogranin A	167 ± 12	211 ± 18	.06
Serotonin	102 ± 8	132 ± 16	.11
Somatostatin	21.8 ± 3	33.67 ± 5	.05
Peptide YY	52.35 ± 4.8	77.29 ± 7.6	.02
Enteroglucagon	35.45 ± 3.8	51.67 ± 5.2	.02
Pancreatic polypeptide	17.55 ± 2.3	24.05 ± 3.5	.04

Data are presented as the mean ± SEM. Comparison: Paired t-test. Total group of IBS patients before and after transplantation. IBS: irritable bowel syndrome.

Bolded p values < .05 are considered significant.

Table 2. The densities of the enteroendocrine cells in the sigmoid colon of the total groups of IBS responder and non-responder patients before and after transplantation.

	Endocrine cells (cells/mm^2)
Hormone	Total responders (n = 10)		Total nonresponders (n = 10)		p Value^a	p Value^b
	Before	After	Before	After
Chromogranin A	160 ± 12	207 ± 27	175 ± 20	215 ± 24	.11	.33
Serotonin	96 ± 7	131 ± 24	107 ± 13	133 ± 22	.17	.41
Somatostatin	20 ± 3	42 ± 9	24 ± 5	25 ± 4	.023	.86
Peptide YY	51 ± 5	81 ± 14	54 ± 8	74 ± 5	.1	.07
Enteroglucagon	33 ± 4	53 ± 8	38 ± 7	50 ± 6	.056	.22
Pancreatic polypeptide	23 ± 3	30 ± 6	12 ± 2	18 ± 3	.12	.23

Data are presented as the mean ± SEM. Comparison: Paired t-test.

^aTotal group of responders before and after transplantation

^bTotal group of IBS non-responders before and after transplantation. IBS: irritable bowel syndrome.

Bolded p values <. 05 are considered significant.