Abstract
Background and aim
Gastroesophageal reflux disease (GERD) is one of the most common digestive disorders, which seriously affects the quality of life and brings a heavy burden to the medical care. Peroral endoscopic cardial constriction (PECC) can narrow the cardia through mucosal ligation to alleviate acid reflux symptoms. This study aims to assess the clinical efficacy of PECC.
Methods
This was a retrospective case series including patients diagnosed with GERD and undergoing PECC from September 2019 to July 2021. GERD-Q questionnaire and GERD-QOL questionnaire were applied to evaluate the symptom severity and the impact of life because of GERD.
Results
A total of 16 patients were included in our study. The mean GERD-Q score was 10.94 ± 2.11 before PECC, while 5.38 ± 3.90 after PECC. The mean GERD-QOL score was 43.60 ± 16.94 before PECC, while 73.65 ± 22.08 after PECC. 62.5% of patients were satisfied with the symptom control and no serious complications were reported in our study.
Conclusions
PECC is an efficient and safe minimally invasive endoscopic intervention for GERD. It can significantly improve GERD-related symptoms and quality of life.
Ethics approval and consent to participate
The study was approved by the Clinical Research Ethics Committee of the First Affiliated Hospital, Zhejiang University College of Medicine (No.2021-672).
Written informed consent was obtained from all patients at the time of endoscopy.
All clinical investigations were conducted in accordance with the ethical guidelines of the Declaration of Helsinki.
Author contributions
Guarantor of the article: Zhe Shen.
Wenxi Jiang, Guangwu Chen, Chaohui Yu, and Zhe Shen conceived and designed the study. Wenxi Jiang, Guangwu Chen, Caijuan Dong, Shefeng Zhu, Jiaqi Pan, Zhaoxue Liu, and Meng Li collected and analyzed the data. Wenxi Jiang, Guangwu Chen, Caijuan Dong, Shefeng Zhu, Jiaqi Pan, Zhaoxue Liu, Meng Li, Chaohui Yu, and Zhe Shen wrote the article.
Disclosure statement
All authors disclosed no financial relationships relevant to this publication and disclosed no conflicts of interest.