Emergency subtotal colectomy rates in relation to anti-TNF therapy in inflammatory bowel disease patients: comparison of retrospective cohorts

Figures & data

Figure 1. Flowchart of study cohort.

Table 1. Overview of clinical characteristics of patients who underwent emergency subtotal colectomy for inflammatory bowel disease acute severe colitis at Skåne University Hospital, Sweden, during 2004–2009 and 2012–2017.

	2004–2009 (n = 42)	2012–2017 (n = 49)	All patients (n = 91)	p-Value
Age (years)	37 (27–52)	31 (26–52)	34 (26–51)	.52
Female sex	16 (38)	22 (45)	38 (42)	.53
Comorbidity	10 (24)	11 (22)	21 (23)	1.00
Length of hospital stay (days)	26 (16–31)	25 (18–36)	25 (16–33)	.32
Length of postoperative hospital stay (days)	9 (7–13)	12 (8–20)	9 (8–17)	.071
In-hospital intravenous corticosteroids	33 (79)	38 (78)	71 (78)	.61
Missing data	2	0	2
No. days on intravenous corticosteroids (days)	8 (3–16)	8 (2–11)	8 (3–13)	.24
Missing data	2	0	2
Surgical approach				.001
Laparoscopic	0 (0)	11 (22)	11 (12)
Open	42 (100)	38 (78)	80 (88)
Histopathological diagnosis				.29
Ulcerative colitis	25 (60)	35 (71)	60 (66)
Crohn’s disease	3 (7)	5 (10)	8 (9)
Indeterminate colitis	14 (33)	9 (18)	23 (25)

Values are shown in numbers and percentages in parentheses for categorical variables. Continuous variables are expressed as median and interquartile range.

Bold values highlight results with significant p-values (p ≤ .05).

Table 2. Administration, drug regimen and timing of anti-TNF therapy in patients who underwent emergency subtotal colectomy for inflammatory bowel disease acute severe colitis at Skåne University Hospital, Sweden, during 2004–2009 and 2012–2017.

	2004–2009 (n = 42)	2012–2017 (n = 49)	All patients (n = 91)	p-Value
Patients who received anti-TNF therapy prior to admission	12 (29)	31 (63)	43 (47)	.001
Patients who received anti-TNF therapy after admission	17 (40)	22 (45)	39 (43)	.83
Drug types used after admission				.68
Infliximab	15 (88)	18 (82)	33 (85)
Adalimumab	2 (12)	4 (18)	6 (15)

Values are shown in numbers and percentages in parentheses.

Bold value highlights result with significant p-values (p ≤ .05).

Table 3. Number of emergency subtotal colectomies performed at Skåne University Hospital in relation to disease prevalence of inflammatory bowel disease in Skåne county during 2004–2009 and 2012–2017.

	2004–2009	2012–2017
Number of emergency subtotal colectomies	42	49
Person years with inflammatory bowel disease	29095	35865
Emergency subtotal colectomies per 1000 person years (95% CI)	1.44 (1.05 − 1.93)	1.37 (1.02 − 1.79)

Table 4. Postoperative complications within 30 days in patients who underwent emergency subtotal colectomy for inflammatory bowel disease acute severe colitis at Skåne University Hospital, Sweden, during 2004–2009 and 2012–2017.

	2004–2009 (n = 42)	2012–2017 (n = 49)	All patients (n = 91)	p-Value
Overall	19 (45)	20 (41)	39 (43)	.68
Infectious	5 (12)	8 (16)	13 (14)	.76
Cardiovascular	2 (5)	4 (8)	6 (7)	.68
Neurological	2 (5)	1 (2)	3 (3)	.59
Surgical	13 (31)	13 (27)	26 (29)	.65
Unplanned re-operation	5 (12)	6 (12)	11 (12)	1.00
Unplanned re-admission	5 (12)	3 (6)	8 (9)	.46
30-day mortality	2 (5)	0 (0)	2 (2)	.21

Values are shown in numbers and percentages in parentheses.

Data availability statement

The data that support the findings of this study are available from the corresponding author, SS, upon reasonable request.