Performance and safety of diagnostic EUS FNA/FNB and therapeutic ERCP in patients with borderline resectable and locally advanced pancreatic cancer - results from a population-based, prospective cohort study

Figures & data

Figure 1. Pathologic findings of samples collected during 268 EUS FNA and/or FNB procedures in 223 patients with a radiological diagnosis of BRPC or LAPC.

Table 1. Patient characteristics and tumor details for 223 patients undergoing EUS FNA/FNB.

	Overall
Patient characteristics	223
Age, median years (IQR)	70 (64–75)
Gender, n (%)
Male	118 (52.9)
Female	105 (47.1)
ECOG status n (%)
0	124 (55.6)
1	74 (33.2)
2	19 (8.5)
3	6 (2.7)
4	0 (0)
Charlson comorbidity index, median score (IQR)	5 (4-6)
Tumor characteristics
Localization, n (%)
Head	139 (62.3)
Neck	10 (4.5)
Uncinate	34 (15.2)
Body	35 (15.7)
Tail	5 (2.2)
Tumor size, mm (IQR)	35.5 (29-45)
Tumor classification, n (%)
Borderline resectable	111(49.8)
Locally advanced	112 (50.2)

Table 2. Patient and treatment characteristics for 133 patients undergoing primary ERCP with placement of a biliary stent.

Patient characteristics	Overall
Total no.	133
Age, median years (IQR)	71 (64-76)
Gender, n (%)
Male	72
Female	61
ECOG status n (%)
0	62
1	46
2	16
3	9
4	0
Charlson comorbidity index, median (IQR)	5 (4–6)
Tumor characteristics
Localization n (%)
Head	111
Neck	7
Body	0
Tail	0
Uncinate	15
Tumor size mm (IQR)	33 (28–42)
Tumor classification
Borderline resectable	77
Locally advanced	56
Number of attempts
One attempt, n (%)	133 (100)
Two attempts, n (%)	16 (12)
Success rate
First attempt, n (%)	107 (80.5)
Second attempt, n (%)	15 (93.8)
Type of stent
Metal stent, n (%)	107 (87.7)
Plastic stent, n (%)	15 (12.3)
Proceeded to PTBD^a, n (%)	11 (8.3)^b

^a 10 patients proceeded to PTBD after the first ERCP attempt, 1 patient after the second attempt.

^b In addition 5 patients underwent primary PTBD without prior ERCP attempt.

Table 3. Postprocedural adverse events after ERCP, PTC or EUS FNA/FNB.

	ERCP (N = 149)				PTBD (N = 16)	EUS (N = 268)
Adverse event	Overall	Metal stent	Plastic stent	No stent	Overall	Overall	FNA	FNB	FNA/FNB	COMBINED EUS/ ERCP (N = 41)
Pancreatitis	12	11	1			7	3	1	3	3
Cholangitis	4	1	1	2	2	1	1	0	0	0
Perforation	1	0	0	1		0	0	0	0	0
Immediate stent failure	1	1	0		1	0	0	0	0	0
Bacteremia	1	1	0			0	0	0	0	0
Bleeding	1	0	0	1		0	0	0	0	0
Other, not specified	3^a	0	2	1	1^b	0	0	0	0	1^c
Total, n (%)	23 (15.4)	21	2		4 (25)	8 (3)	4	1	3	4 (9,8)

^a One patient experienced airway obstruction and respiratory difficulties during ERCP. Two patients developed renal failure following dehydration and prolonged procedures.

^b One patient had immediate bile leakage and dislocated stent.

^c One patient developed renal failure following dehydration and prolonged procedure.

Data access statement

The data presented in this study are available upon reasonable request from the corresponding author. The data are not publicly available due to privacy regulations.