Increasing the transplant dose and repeating faecal microbiota transplantation results in the responses of male patients with IBS reaching those of females

Figures & data

Table 1. Characteristics of patients included in the study at baseline.

	Total	Females	Males	p
Number	186	131	55
Age, years	37.1 ± 12.7	36.4 ± 12.5	39.0 ± 12.9	0.2
Body mass index, kg/m^2	24.9 ± 5.2	24.7 ± 5.4	25.9 ± 4.1	0.1
IBS-diarrhoea	69	50	19
IBS-constipation	64	45	19	0.9
IBS-mixed	53	36	17
IBS duration, years	22.9 ± 13.5	23 ± 13	23 ± 15	0.8
Total IBS-SSS score	345.7 ± 76.8	355.4 ± 72.8	336.2 ± 80.8	0.1
Birmingham IBS Symptom Questionnaire total score	26.2 ± 6.1	26.6 ± 5.7	25.1 ± 6.3	0.1
FAS total score	34.2 ± 5.2	34.5 ± 5.0	33.5 ± 5.5	0.3
Total IBS-QoL score	97.9 ± 20.9	96.2 ± 20.7	102.3 ± 21.0	0.09
Total SF-NDI score	34.7 ± 7.2	34.4 ± 7.1	35.5 ± 7.3	0.3
DI	2.3 ± 1.0	2.2 ± 1.0	2.5 ± 1.0	0.01
Proton-pump inhibitor	23 (12.4)	12 (9.2)	11 (20)	0.05
Painkiller	20 (10.8)	15 (11.5)	5 (9.1)	0.8
Antidepressant	28 (15.1)	20 (15.3)	8 (14.5)	0.5
Birth-control drug	51 (38.9)	51 (38.9)	0 (0)	<0.0001
Asthma/allergy drug	43 (23.1)	32 (24.4)	11 (20)	0.6
Levothyroxine-containing drug	3 (1.6)	3 (2.3)	0 (0)	0.6
Heart/vascular drug	11 (5.9)	8 (6.1)	3 (5.5)	>0.999

Data are mean ± SD, n or n (%) values.

Figure 1. Response rates of females and males to FMT in the total patient cohort (A) and in the LI (B), SI (C) and R (D) groups. ns, not significant.

Figure 2. Total IBS-SSS scores in females and males in the total patient cohort (A) and in the LI (B), SI (C) and R (D) groups. *, p < 0.05.

Figure 3. Birmingham IBS Symptom Questionnaire total scores for females and males in the total patient cohort (A) and in the LI (B), SI (C) and R (D) groups. *, p < 0.05; **, p < 0.01.

Figure 4. FAS total scores for females and males in the total patient cohort (A) and in the LI (B), SI (C) and R (D) groups.

Figure 5. Total IBS-QoL scores in females and males at different times after FMT in the total patient cohort (A) and in the LI (B), SI (C) and R (D) groups. *, p < 0.05; **, p < 0.01.

Figure 6. Total SF-NDI scores in females and males at different times after FMT in the total patient cohort (A) and in the LI (B), SI (C) and R (D) groups.

Figure 7. Levels of Alistipes spp. in females and males at baseline and at different times after FMT in the total patient cohort (A) and in the LI (B), SI (C) and R (D) groups. *, p < 0.05; **, p < 0.01.

Data availability statement

Data obtained in this study are available from the corresponding author on request.