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Original Articles

Quantitative Infrared Spectroscopy in the Undergraduate Laboratory Via Multivariate Mixture Analysis of a Simulated Analgesic

, &
Pages 539-544 | Received 01 Sep 2009, Accepted 26 Oct 2009, Published online: 20 Oct 2010
 

ABSTRACT

Infrared spectroscopy has been utilized for nearly a century as a qualitative tool for, at least, partial structure elucidation. More recently, infrared spectroscopy has become a powerful, reliable quantitative analysis tool in industrial chemistry applications, especially in the areas of quality control. Unfortunately, this newer aspect of infrared spectroscopy is often not conveyed during the undergraduate chemical education experiences. We describe an undergraduate laboratory experiment that illustrates the application of infrared spectroscopy combined with multivariate data analysis in the concentration determination of a three-component solid state mixture.

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