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Spectroscopy Letters
An International Journal for Rapid Communication
Volume 49, 2016 - Issue 7
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ORIGINAL ARTICLES

Embryo viability indexing using Raman spectroscopy of spent culture media

Uğur ParlatanFaculty of Science and Letters, Department of Physics Engineering, Istanbul Technical University, Istanbul, Turkey;Department of Engineering Science, Faculty of Engineering, Istanbul University, Istanbul, TurkeyCorrespondence[email protected]
,
Günay BaşarFaculty of Science and Letters, Department of Physics Engineering, Istanbul Technical University, Istanbul, Turkey
,
Nima BaviliFaculty of Science and Letters, Department of Physics Engineering, Istanbul Technical University, Istanbul, Turkey
,
Harika YumruDepartment of Obstetrics and Gynecology, Istanbul University School of Medicine, Istanbul, Turkey
,
Fatih SagDepartment of Obstetrics and Gynecology, Istanbul University School of Medicine, Istanbul, Turkey
,
Sibel BulgurcuogluDepartment of Obstetrics and Gynecology, Istanbul University School of Medicine, Istanbul, Turkey
&
Ercan BastuDepartment of Obstetrics and Gynecology, Istanbul University School of Medicine, Istanbul, Turkey
 show all
Pages 458-463 | Received 25 Jan 2016, Accepted 03 Jun 2016, Published online: 10 Jun 2016
 
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ABSTRACT

Embryo viability quantification is an important topic for in vitro fertilization researchers. This study suggests Raman spectroscopy as a candidate method to find an objective measure of embryo viability. Raman spectra of 31 spent embryo culture samples (16 nonpregnant, 15 pregnant) from 31 patients were analyzed with band component analysis. The band area ratio of 902 to 943 cm−1 was found to be the most discriminatory. These bands are related to glutamine, glycine, proline, aspartic acid, and valine. According to the pregnancy outcome the sensitivity and specificity of Raman analysis were found to be 93% and 77%, respectively.

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