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Spectroscopy Letters
An International Journal for Rapid Communication
Volume 39, 2006 - Issue 2
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Original Articles

Proton Decoupled 19F NMR Spectroscopy of Drugs Used in Eye Treatment

Oddbjørn Sæther Department of Neuroscience, and Department of Physics, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayCorrespondence[email protected]
,
Anna Midelfart Departments of Ophthalmology and Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
,
Øystein Risa Department of Neuroscience, and Department of Physics, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
,
Olav Haraldseth Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Medical Imaging, St. Olav's Hospital, Trondheim, Norway
&
Jostein Krane Department of Chemistry, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
Pages 135-144 | Received 29 Jan 2005, Accepted 12 Aug 2005, Published online: 22 Sep 2006
 
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Abstract

The potential for detecting fluorinated compounds in a 2.35 T nuclear magnetic resonance system was assessed to evaluate the possibility for in vivo monitoring of fluorinated drugs applied to the eye. Time‐share proton decoupled 19F NMR spectroscopy was implemented for signal enhancement in an experimental eye model. Signal‐to‐noise in 19F NMR spectra of dexamethasone phosphate was enhanced by 56%. However, decoupling did not enhance S/N for ciprofloxacin. The obtained detection limit of 0.1–0.2 µmol did not enable detection of drugs at therapeutic concentrations in the eye. Higher magnetic field and improved coil and detection technology might enable future in vivo monitoring of drugs in the eye.

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