Acylation Studies with Meldrum's Acid

Abstract

Meldrum's acid (1) on bisacylation with succinyl chloride afforded a neutral diketo product (2); however, the dimer enolic products (3) with acidic nature resulted in glutaryl and adipyl dichlorides. Monoacylation of (1) with acetyl chloride gave acidic 5‐acetyl Meldrum's acid (4) in enol form.

Presented at the National Symposium on Newer Concepts in Organic Synthesis, 1998, Aurangabad, India, [Abstract: 1.29].

This paper is dedicated to Prof. M. M. Salunkhe, Vice-Chancellor, Shivaji University, Kolhapur–416 004 (Former Director, Institute of Science, Mumbai – 400 032) India.

Keywords:

• Meldrum's acid
• acylation

Acknowledgment

We thank the University Grants Commission, New Delhi, India, for financial assistance.

Notes

Presented at the National Symposium on Newer Concepts in Organic Synthesis, 1998, Aurangabad, India, [Abstract: 1.29].

This paper is dedicated to Prof. M. M. Salunkhe, Vice-Chancellor, Shivaji University, Kolhapur–416 004 (Former Director, Institute of Science, Mumbai – 400 032) India.