N‐Linked Hydroxylamine Resin: Solid‐Phase Synthesis of Hydroxamic Acids

Abstract

A novel hydroxylamine resin for solid‐phase synthesis of hydroxamic acids is described. Its facile application is illustrated by the solid‐phase synthesis of various hydroxamic acids. Cleavage is induced under acidic conditions by treatment with trifluoroacetic acid, providing hydroxamic acids in high purity and good yields.

Keywords:

• Hydroxamic acids
• hydroxylamine resin
• solid‐phase synthesis