Efficient Synthesis of Chiral 1,1′‐Sulfonyl Bisaziridines

Abstract

An efficient three‐step synthesis of chiral 1,1′‐(sulfonyl)bisaziridines is described. Preparation of these compounds was carried out easily starting from N,N′‐sulfonyl bis‐(α‐L‐aminoester) to afford the title compounds in very good yields. These 1,1′‐(sulfonyl)bisaziridines can constitute interesting synthetic building blocks.

Keywords:

• Sulfonylbisaziridine
• sulfamide
• aziridine
• heterocycle

Acknowledgments

Financial support of this work by the Ministère Algérien de l'Enseignement et de la Recherche Scientifique (Fond National de la Recherche FNR2000, Algéria) and Agence Nationale pour la Recherche sur la Santé (ANDRS, project no. 05/05/00039) is gratefully acknowledged.