Oxidative Cyclization of Aromatic Aldehyde N‐Acylhydrazones by bis(Trifluoroacetoxy)iodobenzene

Abstract

Aromatic aldehyde N‐acylhydrazones were oxidized into 2,5‐disubstituted 1,3,4‐oxadiazoles with bis(trifluoroacetoxy)iodobenzene in CHCl₃ or DMSO at room temperature in good to excellent yields.

Keywords:

• Aromatic aldehyde N‐acylhydrazone
• bis(trifloroacetoxy)iodobenzene
• oxidation
• 1,3,4‐oxadiazole

Acknowledgments

I acknowledge support from an Outstanding Young Scholarship (No. 30125043) from the National Science Foudation of China, the Basic Research Project (No. 2002CCA01500) of the Ministry of Science and Technology of China, and the Hebei University of Science and Technology.