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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 1
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Original Articles

Efficient Biginelli Reaction Catalyzed by Sulfamic Acid or Silica Sulfuric Acid under Solvent‐Free Conditions

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Pages 47-52 | Received 08 Jun 2006, Published online: 25 Jul 2007
 

Abstract

Sulfamic acid efficiently catalyzes the three‐component condensation reaction of aldehydes, 1,3‐dicarbonyl compounds, and urea/thiourea under solvent‐free conditions to afford the corresponding dihydropyrimidinones and thio‐derivatives in high yields. Silica sulfuric acid is also found to be an efficient catalyst for the Biginelli reaction under solvent‐free conditions. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of giving good yields and requiring short reaction times.

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