Intramolecular Amidation: Synthesis of Novel Thiazole‐Fused Diazepinones

Abstract

A new class of thiazole‐fused diazepinones has been synthesized by the application of intramolecular hydrazonolysis, wherein 2‐arylamino‐4‐coumarinyl‐5‐formyl thiazoles were treated with hydrazine hydrate in refluxing ethanol to yield the rearranged products via an interesting ring‐opening and cyclization process.

Keywords:

• diazepinone
• intramolecular amidation
• thiazole derivatives

Acknowledgment

Authors thank C. S. Mahajanshetti, former chairman, Department of Chemistry, Karnatak University, Dharwad, India, for valuable suggestions and encouragement.