Facile Synthesis of 3,3‐Dialkyl‐6‐phenyl‐imidazopyridinones

Abstract

A series of novel 3,3‐dialkylated imidazopyridinones bearing 6‐aryl groups were designed as mimetics of active progesterone antagonists, 3,3‐disubstituted‐5‐arylindoles. The four‐step synthetic route is described. The key steps are base‐catalyzed cyclization, base‐catalyzed alkylation, and Suzuki coupling reaction.

Keywords:

• cyclization reaction
• imidazopyridinone
• Suzuki coupling reaction