Abstract
6‐Substituted‐dibenzo[d, f][1,3,2]dioxaposphepin‐6‐oxides, sulfides, and selenides (5a–i, 6a–d, and 7a–d) were synthesized by reacting 2,2′‐biphenol (1) with phosphorus tribromide in the presence of triethylamine at 0–30°C and subsequent reaction of the monobromide (2) with different Grignard reagents (3) at room temperature. The products (4) were converted to corresponding oxides, sulfides, and selenides (5a–i, 6a–d, and 7a–d) by oxidation with H2O2 at room temperature and refluxing with sulfur and selenium respectively. The chemical structures of all the products were confirmed by analytical, IR, NMR (1H, 13C, and 31P), and mass spectral data. Most of these compounds exhibited moderate antimicrobial activity.
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