Synthesis of Novel Pyrrolo[1′,5′‐a]‐1,8‐naphthyridine Derivatives through a Facile One‐Pot Process

Abstract

Novel pyrrolo[1′,5′‐a]‐1,8‐naphthyridine compounds have been synthesized through a facile one‐pot process by the reaction of the corresponding 1,8‐naphthyridines with aliphatic anhydride. The structures were established by spectroscopic data. Further X‐ray crystal analysis of 4′‐acetyl‐7‐methyl‐pyrrolo[1′,5′‐a]‐1,8‐naphthyridine (1) identifies its intriguing molecular structure and reveals the strong π‐π stacking.

Keywords:

• cyclocondensation reaction
• indolizine
• 1,8‐naphthyridine

Acknowledgment

We are grateful to the State Key Project (No. 2005CCA06800) for financial support. We thank the Foundation (50418010) for National Natural Science Foundation of China/Research Grants Council of Hong Kong (NSFC/RGC) Joint Research.