Abstract
Synthesis of 2,2‐bis(hydroxymethyl)methylenecyclopropane (2) is described. Cyclopropane dicarboxylate 3 was reduced to diol 4, which was acetylated to give diacetate 5. Acetoxy‐bromo elimination afforded methylenecyclopropane 6. Debenzylation gave the title compound 2.
Acknowledgments
We thank L. M. Hryhorczuk from the Central Instrumentation Facility, Department of Chemistry, Wayne State University, for mass spectra. The work described herein was supported by SBIR Grant 5 R44 AI0554135 to Microbiotix, Inc., Worcester, Massachusetts, and Research Grant 1 RO1 CA32779 from the National Institutes of Health, Bethesda, Maryland, USA.