Abstract
An efficient method for the one-pot synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles has been developed using trichloroisocyanuric acid (TCCA) at ambient temperature. A wide variety of aromatic as well as heterocyclic aldehydes exhibit condensation with a variety of acylhydrazines followed by oxidative cyclization to yield corresponding unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles. The mild nature of the synthesis and short reaction time are notable advantages of the developed protocol.
ACKNOWLEDGMENT
Authors (D.M.P., U.V.D.) thank University Grants Commission, New Delhi, for financial assistance [F.33–260/2007(SR)].
Notes
a Yields refer to pure isolated products.
a Yields refer to pure isolated products.
b All products gave satisfactory spectroscopic (IR, 1H NMR and 13C NMR) analysis.