Abstract
An unusual chemical method has been applied for the preparation of 1-benzothiophene-3-carboxamide derivatives from esters by reaction with lithium amide in tetrahydrofurane.
ACKNOWLEDGMENTS
The authors thank Ildikó Szilágyi, István Varga, Zoltán Horváth, and Péter Markó for their technical contributions to this work and Csaba Peltz (EGIS Ltd.) for the elemental analysis. This work was supported by OTKA-T-049478, NKFP-1A0020/2002 (MOL.DIAG), NKFP-1A005_04 (MEDICHEM2), and New Medicines for Tuberculosis (LSHP-CT-2005–018923) grants.