Abstract
Reaction of poly(ethylene glycol) (PEG)–bound sulfonic acid with thionyl chloride formed difunctionalized PEG-bound sulfonyl chloride, which was treated with α-hydroxyketones, followed by treatment with thioamides in the presence of potassium carbonate, to afford thiazoles in good yields with a facile workup procedure.
ACKNOWLEDGMENT
We gratefully acknowledge financial support from the National Natural Science Foundation NSF of China (No. 20562005) and NSF of Jiangxi Province (Nos. 0620021 and 2007GZW0185).
Notes
a Yields refer to the isolated pure products based on PEG-bound disulfonyl chloride.
b With the first regenerated resin.
c With the second regenerated resin.
d With the fourth regenerated resin.