Abstract
A simple and general method has been developed for the one-pot, three-component synthesis of a variety of primary 1-aminophosphonates catalyzed by Al(OTf)3 under solvent-free conditions in good to high yields.
ACKNOWLEDGMENTS
We are thankful to Birjand University Research Council for the support of this work.
Notes
a Isolated yield.
a Conditions: carbonyl compound/diethyl phosphite/(NH4)2CO3: 1/1/0.5.
b Conditions: carbonyl compound/diethyl phosphite/NH4OAc: 1/1/1.
c Yields refer to those of pure isolated products characterized by spectral data.
d Reaction occurred immediately.
e Conditions: therephethaldehyde/diethyl phosphite/(NH4)2CO3: 1/2/1.
f Conditions: therephethaldehyde/diethyl phosphite/NH4OAc: 1/2/2.