Triselenium Dicyanide (TSD) as a New Cyanation Reagent: Synthesis of Cyano Pterins and Quinoxalines Along with Library of Cyano N-Heterocyclic Compounds

Abstract

Triselenium dicynide (TSD) has been reported for the first time to be a novel cyanation reagent for the microwave-assisted one-pot synthesis of a series of various types of cyano N-heterocycles such as pterin, deazapterin, quinoxaline, naphthyridine, and pyridine in good yields.

Keywords:

• Cyanation
• heterocyclic compounds
• microwave
• selenium dioxide
• triselenium dicyanide

ACKNOWLEDGMENTS

We thank DST [SR/S1/OC-13/2005], government of India, for financial support. A. C. M. thanks the UGC, government of India, for the fellowship, and we appreciate mass spectral help from Professor Thomas Schrader of Duisburg-Essen University, Essen, Germany.

Notes

^a Reactions were monitored by TLC analysis.

^b A domestic BPL-Sanyo microwave oven (800G) was used. All the reactions were safe.

^c Yields refer to the isolated pure products after column chromatography.