Ionic Liquid [bmim]BF₄ as an Efficient and Recyclable Reaction Medium for the Synthesis of O-Acetyl Cyanohydrin via One-Pot Condensation of Aldehyde, TMSCN, and Ac₂O

Abstract

Ionic liquid [bmim]BF₄ has been demonstrated to be an efficient and environmentally friendly reaction medium as well as reaction promoter for the synthesis of O-acetyl cyanohydrin via one-pot condensation of aldehyde, TMSCN, and Ac₂O without Lewis acid or any special activation. In addition, the recovered ionic liquid could be reused for subsequent runs without the loss of activity.

Keywords:

• Acylation
• ionic liquids
• O-acetyl cyanohydrin
• one-pot reaction
• recycle

ACKNOWLEDGMENT

This work was partially supported by the Key Laboratory of Organic Synthesis of Jiangsu Province at Suzhou University (No. S8109108), the Natural Science Foundation of Jiangsu Province (No. BK2006048), the National Science Foundation of China (Nos. 20472062 and 20672079), the Nature Science Key Basic Research of Jiangsu Province for Higher Education (Nos. 06KJA15007 and 05KJB150116), the Jiangsu Provincial Key Laboratory of Fine Petrochemical Technology (KF0402), and a research grant from the Innovation Project for Graduate Students of Jiangsu Province.

Notes

^a Isolated yield.

^a Isolated yield.