Novel Synthesis of Anthelmintic Drug 4-Isothiocyanato-4′-nitrodiphenyl Ether and Its Analogs

Figures & data

Scheme 1 Synthesis of isothiocyanate.

Scheme 2 Synthesis of 4-isothiocyanato-4′-nitrodiphenyl ether.

Table 1. Synthesis of various isothiocyanates using ferrous sulfate

Sr. No.	Substrate	Product	Time (h)	Yield (%)
1			2	95
2			2	94
3			2.5	72
4			2.5	78
5			2	84
6			2	76
7			3.5	84
8			3	79
9			3	80
10			3	69
11			3	68
12			3.5	65