Abstract
Bromination of aromatic hydrocarbons is triggered by Vilsmeier–Haack reagent [N,N-dimethyl formamide (DMF–POCl3 system)] in the presence of KBr or N-bromosuccinimide (NBS) under solvent-free conditions by grinding the reactants in a mortar with a pestle. The reactions afforded corresponding bromo derivatives in very good yield with high regioselectivity. The results are comparable with those obtained under reflux conditions.
ACKNOWLEDGMENTS
The authors thank Prof. T. Navaneeth Rao (former vice-chancellor, Osmania University, Hyderabad) and the Management Committee of Siddhartha P. G. College, Hyderabad, for constant encouragement. The authors thank the council of scientific and Industrial research (CSIR), New Delhi, for financial assistance in the form of an emeritus scientist appointment accorded to Prof. P. K. Saiprakash.
Notes
Note. VHR = DMF + POCl3; temp. = 313 K.