Heterocyclic Synthesis Using Nitrilimines, Part 12: Synthesis and Bioactivity of 5-Carboxymethylthio-1,2,4-triazoles

Abstract

The reaction of 4-amino-5-phenyl-3,5-thiaaza-4-pentenoic acid 3 with various nitrilimines 2 led to the formation of substituted carboxymethylthio derivatives of 1,2,4-triazoles (4a–l) rather than the amino derivatives 5 or imidazole derivatives 6. The spectral data of the synthesized compounds are in full agreement with its molecular structure.

Keywords:

• 4-Amino-5-phenyl-3,5-thiaaza-4-pentenoic acid
• 5-carboxymethylthio-1,2,4-triazoles
• cycloaddition
• nitrilimines

ACKNOWLEDGMENT

The author thanks the Ministry of Higher Education for financial support and Dr. A. S. Abu Samaha for providing the antimicrobial testing facility for the synthesized compounds.