NaOAc-Mediated Selective Deprotection of Aromatic Acetates and Its Application in the Synthesis of Natural Products

Abstract

We have developed an efficient method to deacetylate the aromatic acetates using NaOAc in excellent yields and demonstrated the application of the procedure in the synthesis of natural products.

Keywords:

• Aromatic acetates
• deacetylation reaction
• flavanone
• NaOAc
• prenylatedchalcones
• selective deprotection

ACKNOWLEDGMENTS

The authors are thankful to the Central Drug Research Institute (CDRI) for support during the synthesis of antiparasitic agents, the Sophisticated Analytical Instrumentation Facility (SAIF) Division of CDRI for spectral data, and the Council of Scientific and Industrial Research New Delhi, for financial support.

Notes

^a Isolated yields.

^b No reaction.

CDRI Communication No. 7574.