Abstract
The first total synthesis of naturally occurring (Z)-11-(2-oxopropylidene)-2,3,11,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(10H)-one,a unique cycloanthranilylproline derivative, has been achieved from readily available anthranilic acid in five steps.
ACKNOWLEDGMENTS
The authors thank Dr. Reddy's Laboratories Ltd. for supporting this work and Mr. Abijit Mukherjee and Dr. Vilas Dahanukar of Custom Pharmaceutical Services for their continuous support and encouragement. The cooperation extended by all colleagues of the analytical division is gratefully acknowledged.