Aminolysis of 3-Phenyl Propylthiol Esters Leading to Diverse Sets of Amides

Abstract

3-Phenyl propylthiol esters were investigated as “activatable” solution phase linkers. These linkers can be activated with silver salts and upon treatment with amines can be converted to the corresponding amides. Under unactivated conditions, the linker is stable to a variety of reagents and reaction conditions including treatment with amines.

Keywords:

• Activatable linkers
• amides synthesis
• solid phase synthesis
• thioesters