Abstract
A three-component Mannich-type reaction of aromatic aldehydes, anilines, and cyclohexanone in the presence of Amberlyst-15 affords the corresponding β-amino ketones in good yields at room temperature. The conversion is highly diastereoselective, favoring the formation of anti-isomers.
ACKNOWLEDGMENTS
The authors thank the Council of Scientific and Industrial Research and the University Grants Commission, New Delhi, for financial assistance.
Notes
a The structures of the products were determined from their 1H NMR and MS data.
b The ratio of syn and anti was determined from the 1H NMR spectra of the crude products.
Part 175 in the series “Studies on Novel Methodologies.”