Application of Enantiopure 1-(Aminoalkyl)naphthols and 2-(Aminoalkyl)phenols in the Enantioselective Addition of Organozinc to α,β-Unsaturated Carbonyl Compounds

Abstract

Several enantiopure 1-(aminoalkyl)naphthols and a 2-(aminoalkyl)phenol were tested as ligands in the Nickel-catalyzed enantioselective addition of organozinc to chalcones.

Keywords:

• 1-(Aminoalkyl)naphthols
• 2-(aminoalkyl)phenols
• chalcones
• enantioselective conjugated addition

Notes

^a Yield of the pure isolated enantiomers mixture.

^b Determined by HPLC analysis. The absolute configuration of the major enantiomer is (R).

^c Ref. 6.

^d Ref. 7.

^a Yield of the pure isolated enantiomer mixture.

^b Determined by HPLC analysis (see Experimental).

^c Absolute configuration of the major isomer.