Simple and Efficient Method for Synthesis of Novel 4-Substituted 1-Acylthiosemicarbazides via One-Pot Multicomponent Reactions

Abstract

A new one-pot, multicomponent condensation reaction of aldehydes, 2-naphthol, and 1-acylthiosemicarbazides is described as an efficient method for the synthesis of novel 4-substituted 1-acylthiosemicarbazides in the presence of p-toluenesulfonic acid (p-TSA) as a catalyst under two conditions: organic solvent and solvent-free media. The present procedure offers several advantages, such as good yields, low cost, and very easy workup.

Keywords:

• Acylthiosemicarbazide
• condensation
• naphthol
• one-pot reaction
• solvent-free

ACKNOWLEDGMENT

We gratefully acknowledge the financial support from the Research Council of Arak University.

Notes

^a 10 mol%.

^b Isolated yields.

^a Method A: reactions were carried out with 10 mol% of p-TSA in CH₂Cl₂ at room temperature. Method B: reactions were carried out with 5 mol% of p-TSA under solvent-free conditions at 125°C.

^b Isolated yields.