Abstract
An expeditious novel approach to 3,6-disubstituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles using silica-supported dichlorophosphate as a recoverable cyclodehydrant, carboxylic acids and thiocarbohydrazide as starting materials, and microwave irradiation as thermal source was described. The protocol has advantages of concise synthetic step, short time, good yield, easy workup procedure, and no environmental pollution.
ACKNOWLEDGMENTS
The authors thank the National Natural Science Foundation of China (20772096) and Gansu Natural Science Foundation (3ZS061-A25-033) for the financial support of this work.
Notes
a The yields refer to the isolated product.