Abstract
By diazotization of 2-aminothiazoles and reaction with sodium azide, the derivatives of 2-azidothiazole were synthesized. Conditions of diazotization were selected according to the nature of a substituent in thiazoles. 2-Azidothiazole derivatives were studied in the base-catalysed condensation reactions with activated methylenic compounds to yield new 1-(1,3-thiazol-2-yl)-1H-1,2,3-triazole-4-carboxylic acids.
Notes
a Isolated yields are based on single experiment and the yields were not optimized.
b No reaction.
c Mixture of H3PO4 (80%) and concentrated HNO3 (2.2:1 by volume).
a All melting points are given for crude products without purification and are uncorrected.
b IR spectra were recorded in CCl4 solution.