Abstract
An efficient, inexpensive, and heterogeneous catalyst, [Al(H2PO4)3], was applied in a three-component, one-pot cyclocondensation reaction of isatoic anhydride with primary amines (or ammonium salts) and aldehydes to afford the corresponding quinazolinone derivatives in excellent yields. Reactions occurred under thermal solvent-free conditions. It was found that this solid acidic catalyst could be easily recovered and reused for at least three cycles without any loss of activity.
ACKNOWLEDGMENT
We are thankful to the Sistan and Baluchestan University Research Council for the partial support of this research.
Notes
a Yield refer to the isolated pure product.
a The reaction was conducted in an oil bath at 100 °C; the molar ratio of isatoic anhydride, primary amines, benzaldehydes, and Al(H2PO4)3 as catalyst was chosen 1:1.1:1:0.16.
a The reaction was conducted in an oil bath at 100 °C; the molar ratio of isatoic anhydride, ammonium salts, benzaldehydes, and Al(H2PO4)3 as catalyst was 1:1.2:1:0.16.
a The molar ratio of isatoic anhydride, benzaldehyde, ammonium acetate, and Al(H2PO4)3 was 1:1:1.2:0.16.
This article is dedicated to Professor Ahmad Akbari, Chancellor of Sistan and Baluchestan University, who dedicates himself to the progress of science.