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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 14
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Original Articles

Facile Preparation of 1,2-Diketones

, &
Pages 2164-2171 | Received 16 Jun 2009, Published online: 17 Jun 2010
 

Abstract

Easily accessible lead-like libraries of heterocyclic molecules useful for high-throughput screening are of continuous interest to the pharmaceutical industry. A number of drug-like libraries are derived from aromatic 1,2-diketones; however, nonsymmetrical 1,2-diketones are challenging to prepare. This communication describes a simple and practical synthesis of 1,2-diketones based on a controlled cross benzoin-like condensation reaction.

Notes

a Isolated yields after distillation.

b Reaction in the absence of ZnI2 catalyst.

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