Abstract
A facile and fast procedure for synthesis of 3-phenyl-cyclohexane(1′-2)thiazolidin-4-one (1), which underwent condensation with glucose and p-chlorobenzaldehyde to afford 2 and 3, respectively. Compound 3 was used as precursor for the preparation of some fused heterocyclic compounds 4–7. Compound 4 was alkylated using dichloroacetone and chloroacetic acid to afford 8 and 9, respectively. Also, it reacted with acrylonitrile and hydrazine hydrate to afford 10 and 11, respectively. Compound 9 was condensed with p-chlorobenzaldehyde and glucose to afford 12 and 13, respectively. Selected members of the synthesized compounds were screened for antimicrobial activity.
ACKNOWLEDGMENT
We are thankful to Dr. Naiera A. M. Abdel Wahed, Natural and Microbial Products Department, National Research Centre, for biological evaluation.
Notes
Notes. Highly sensitive: inhibition zone 21–30 mm.
Fairly sensitive: inhibition zone 16–20 mm.
Slightly sensitive: inhibition zone 10–15 mm.