Abstract
A convergent synthesis of indoprofen via a Buchwald coupling approach is reported. Using this methodology, indoprofen and a set of analogs of indoprofen were readily prepared.
ACKNOWLEDGMENTS
The authors acknowledge Drs. Jill Heemskerk (National Institute of Neurological Disorders and Stroke), John M. McCall (PharMac LLC), Sabina Robinson (Science Applications International Corporation), Amelie Gubitz (National Institute of Neurological Disorders and Stroke), and James A. Romano Jr. (Science Applications International Corporation) for their advice, direction, and support on this project. This project has been funded in whole or in part with federal funds from the National Institute of Neurological Disorders and Stroke, National Institute of Health, under Contract No. N01-NS-3-2356.