Abstract
A general, simple, and environmentally friendly method for the direct amination of secondary benzyl alcohols with amides or 4-nitroaniline is described. This method has been applied to a variety of substrates, and the reaction proceeded smoothly at room temperature under solvent-free conditions. CbzNH2 was proved to be very useful in the direct preparation of the benzylic amines from corresponding alcohols.
ACKNOWLEDGMENT
This work was financially supported by the Natural Science Foundation of China (No. 20672035).
Notes
a Reaction condition: 4-methylbenzenesulfonamide (1.2 mmol), 1-phenylethanol (1 mmol).
b 4-Methylbenzenesulfonamide was ground before use.
c Isolated yield.
a Reaction condition: nucleophile (1.2 mmol), benzylic alcohols (1 mmol), FeCl3 (20 mol%), room temperature.
b Isolated yield.
c When the reactants were both solid, they were ground together and warmed to 60 °C.
a Isolated yield.