Abstract
Epoxide ring opening with thioacetic acid and thiobenzoic acid was investigated in the presence of water under catalyst-free conditions. This green and simple process gave an excellent yield. With simple decanting, the products were obtained in high purity and on a large scale. In this process, alkyl halide and ester cleavage were not observed.
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ACKNOWLEDGMENT
Many thanks go to the Faculty of Chemistry of Tarbiat Moallem University for supporting this work.
Notes
a Isolated yields.
b Isolated yield for large-scale synthesis.
c The yield in parentheses refers to the Michael adduct.