Iodine- and Indium(III) Chloride–Catalyzed Facile Syntheses of 1,5- and 1,8-Naphthyridines

Abstract

Iodine- and InCl₃-catalyzed facile syntheses of 1,5- and 1,8-naphthyridines from 3-aminopyridine and 2-aminopyridines are described. The catalyst InCl₃ could be recovered and reused up to five times efficiently.

Keywords:

• Amino pyridines
• ethylacetoacetate
• glycerol
• naphthyridines

ACKNOWLEDGMENTS

We thank the Department of Science and Technology, New Delhi, India, for financial support of this project under the Green Chemistry Task Force Scheme (No. SR/S5/GC-02A/2006). K. C. is thankful to the Council of Scientific and Industrial Research, New Delhi, for his fellowship.

Notes

^a Isolated yields in an average of minimum two runs.

^b Not detected because of charring.

^c Reaction carried out at a 5.0-g scale of 1, and yields reported are crude product.

^a Isolated yields of purified product 8.

^b Reaction carried out at 80 °C.

^a Isolated yields of purified products.