Abstract
In this research, polysubstituted quinolines are prepared from the reaction of 2-aminobenzophenones and ethylacetoacetate or ketones in the presence of 1-butyl-3-methylimidazolium hydrogen sulfate [bmim]HSO4 as an acidic ionic liquid in good to high yields at 70 °C under solvent-free conditions.
ACKNOWLEDGMENT
We are thankful to the Persian Gulf University Research Council for their partial support of this work.
Notes
a Reaction conditions: 2-aminobenzophenone (1.0 mmol), ethyl acetoacetate (1.0 mmol), reaction temperature 70 °C under solvent-free conditions.
a Reaction conditions: 2-aminobenzophenone (1.0 mmol), dimedone (1.0 mmol), reaction temperature 70 °C under solvent-free conditions.
a Reaction conditions: 2-aminobenzophenone (1.0 mmol), dimedone (1.0 mmol), [bmim][HSO4] (0.5 mmol).
b In this case, [bmim][HSO4] was used as solvent (2 mL).
a Reaction conditions: 2-aminobenzophenones (1) (1.0 mmol), ketones (2) (1.0 mmol), [bmim][HSO4] (0.5 mmol).
b Isolated yield.