Efficient One-Pot Synthesis of 4-Aroyl-2-pyrones: Nucleophilic Addition of Active Methylene Groups to 1,2-Diaroylacetylenes

Abstract

An efficient synthesis of 3,6-disubstituted-4-aroyl-2-pyrones in a single-step reaction through Michael addition of 1,2-diaroylacetylenes with active methylene compounds in the presence of NaH in dimethylsulfoxide at room temperature is reported. The structures have been confirmed by spectral data analyses.

Graphical Abstract

Keywords:

• 4-Aroyl-2-pyrones
• 1,2-diaroylacetylenes
• Michael addition

ACKNOWLEDGMENTS

Ravi Shankar is thankful to the Council of Scientific and Industrial Research for a senior fellowship; Uma Sharan Singh and Harsha Shukla are grateful to the Ministry of Health and Family Welfare for financial assistance; and all authors thank Sophisticated Analytical Instrument Facility (SAIF) for spectroscopic analyses of the compounds.

Notes

CDRI Communication No. 7494.