Abstract
An ecofriendly and efficient microwave-irradiated solvent-free benzoylation method was developed. The procedure for C-benzoylation used 50 mol% AlCl3 as a Lewis acid catalyst at 130 °C and was completed in 10 min. The isolated yield was between 71% and 100%. N-benzoylation was conducted in a catalyst-free environment at 130 °C in 10 min. The isolated yield was between 80% and 100%.
ACKNOWLEDGMENT
Financial support from U.S. Department of Education Title III grant to Tennessee State University is acknowledged.
Notes
a All reactions were run at least two times. The products were purified by silica-gel chromatography using hexane/ethyl acetate (50/1) as the eluent.
a All reactions were run at least two times. The products were purified by silica-gel chromatography using hexane/ethyl acetate (5/1) as the eluent.