One-Pot, Three-Component Synthesis of α-Amino Phosphonates Using NaHSO₄-SiO₂ as an Efficient and Reusable Catalyst

Abstract

A simple, efficient, and environmentally benign method has been developed for the synthesis of α-amino phosphonates. One-pot, three-component reaction of aldehyds, amines, and trialkylphosphite in the presence of silica-supported sodium hydrogen sulfate (NaHSO₄-SiO₂) as an inexpensive and reusable catalyst under solvent-free conditions at 80 °C affords the corresponding α-amino phosphonates in good yields and short reaction times.

GRAPHICAL ABSTRACT

Keywords:

• α-Amino phosphonates
• heterogeneous catalyst
• NaHSO₄-SiO₂
• reusable catalyst
• trialkylphosphite

ACKNOWLEDGMENT

We gratefully acknowledge financial support from the Research Council of the University of Sistan and Baluchestan.

Notes

^a Yields refer to the pure isolated products.

^a Yields refer to the pure isolated products.

^b All known products have been reported previously in the literature and were characterized by comparison of IR and NMR spectra with authentic samples.

^c The new compounds synthesized in this work.

^a Yields refer to the pure recovered catalyst.