Abstract
In this article, we report a facile asymmetric synthesis of the pyrrolo[2,1-a]benzazepine ring system based around a stereoselective N-acyliminium cyclization of a novel chiral lactam template.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
The authors thank Loughborough University for facilities and the EPSRC Eng. D. program and Charnwood Molecular Ltd. for support to J. M. R. Towler. We also thank the STFC for synchrotron beam time at Daresbury Laboratory and J. E. Warren and T. J. Prior for scientific support on Station 9.8.