Abstract
A series of novel halogen-substituted deoxyvasicinone {2,3-dihydro-7-halopyrrolo-[(2,1-b)]-quinazolin-9-(1H)-one and 2,3-dihydro-5,7-dihalopyrrolo-[(2,1-b)]-quinazolin-9-(1H)-one} derivatives was synthesized by condensation of halogenated anthranilic acids (2, 3, 4, 5) with 4-aminobutyric acid (6) in refluxing m-xylene over phosphorus pentoxide for 3 h to give the desired compounds (7a–7d).
GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
The authors thank Gabrielle Jones and Octavia Felton for their assistance during the preparation of this manuscript and the National Institutes of Health (NIH/NIGMS) for support of this work.