Abstract
An efficient procedure for the preparation of aryl azides using sonication is described. The convenient sonication-mediated azidation protocol is applicable to aryl compounds under mild conditions with aqueous solution of sodium dichloroiodate and sodium azide. Aryl azides were obtained in excellent yields from a variety of aryl compounds in short reaction times without affecting sensitive functional groups.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENT
K. A. S. gratefully acknowledges the Council of Scientific and Industrial Research, Delhi, India, for financial support.
Notes
a Reaction conditions: Substrate (1.0 equiv), aqueous solution of sodium dichloroiodate (1.5 M, 1.01 equiv), and sodium azide (1.01 equiv) at room temperature combined with sonication.
b Starting compounds were prepared by standard reported procedures.
c Isolated yields after column chromatography and structures were confirmed by comparison of the IR and 1H NMR spectra with those of authentic materials.[ Citation 3 , Citation 4 , Citation20-22 ]
d No reaction.